Kinesin-8s hang on by a tail
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چکیده
منابع مشابه
Kinesin-8s hang on by a tail
Accurate segregation of genetic material into two daughter cells is essential for organism reproduction, development, and survival. The cell assembles a macromolecular structure called the mitotic spindle, which is composed of dynamic microtubules (MTs) and many associated proteins that assemble the spindle and drive the segregation of the chromosomes. Members of the kinesin superfamily of MT a...
متن کاملThe kinesin-1 motor protein is regulated by a direct interaction of its head and tail.
Kinesin-1 is a molecular motor protein that transports cargo along microtubules. Inside cells, the vast majority of kinesin-1 is regulated to conserve ATP and to ensure its proper intracellular distribution and coordination with other molecular motors. Regulated kinesin-1 folds in half at a hinge in its coiled-coil stalk. Interactions between coiled-coil regions near the enzymatically active he...
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Casein Kinase 2 Reverses Tail - Independent Inhibition of Kinesin - 1
Submitted for the CAL10 Meeting of The American Physical Society Casein Kinase 2 Reverses Tail-Independent Inhibition of Kinesin11 JING XU, ZHANYONG SHU, PREETHA ANAND, BABU REDDY, SILVIA CERMELLI, THOMAS WHISENANT, UC Irvine, STEPHEN KING, University of Missouri-Kansas City, LEE BARDWELL, LAN HUANG, STEVEN GROSS, UC Irvine — Kinesin-1 is a plus-end microtubule-based molecular motor, and defect...
متن کاملCasein Kinase 2 Reverses Tail-Independent Inactivation of Kinesin-1
Kinesin-1 is a plus-end microtubule-based motor, and defects in kinesin-based transport are linked to diseases including neurodegeneration. Kinesin can auto-inhibit via a head-tail interaction, but is believed to be active otherwise. Here we report a tail-independent inactivation of kinesin, reversible by the disease-relevant signalling protein, casein kinase 2 (CK2). The majority of initially ...
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ژورنال
عنوان ژورنال: BioArchitecture
سال: 2011
ISSN: 1949-0992,1949-100X
DOI: 10.4161/bioa.18427